Matrix proteoglycans as effector molecules for epithelial cell function
نویسندگان
چکیده
منابع مشابه
Matrix proteoglycans as effector molecules for epithelial cell function
Matrix proteoglycans are complex molecules composed of a core protein and glycosaminoglycan side chains. Once thought to be the molecular glue providing structural support and imparting biomechanical properties to lung tissue, it is now apparent that proteoglycans are important biological modifiers which regulate processes such as lung development, homeostasis, inflammation and wound healing. T...
متن کاملFunction of proteoglycans in the extracellular matrix.
Proteoglycans are glycosylated proteins which have covalently attached highly anionic glycosaminoglycans. Many forms of proteoglycans are present in virtually all extracellular matrices of connective tissues. The major biological function of proteoglycans derives from the physicochemical characteristics of the glycosaminoglycan component of the molecule, which provides hydration and swelling pr...
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Borrelia burgdorferi adhere to mammalian cells in vitro but neither the ligand(s) nor the receptor(s) has (have) been clearly established. Using an in vitro attachment-inhibition assay, a B. burgdorferi attachment mechanism has been identified. Heparin, heparan sulfate, and dermatan sulfate reduced the attachment of virulent B. burgdorferi strain 297 to HeLa cells by approximately 60%. In addit...
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Introduction The evolution of multicellular organisms made necessary the development of an extracellular matrix to protect cells and to bind them together in a spatial arrangement required for specialized anatomical and physiological functions. Thus the extent of the matrix and how it is organized in different parts of the body depend on the specialized functions of cells. The matrix in its tur...
متن کاملEpithelial cells, Exracellular matrix
چکیده مقدمه: ماده خارج سلولی به عنوان بخش مهم ریز محیطMicroenvironment)(، نقش اساسی در نگهداری وضعیت تمایز دارد. در بررسی‌های گذشته، این اثر در برخی سلول‌ها از جمله سلول‌های پوششی لوله رحم و یا رحم مطالعه شده است. در این پژوهش‌ها، برای حفظ تمایز سلول ، علاوه بر ماده خارج سلولی عوامل دیگر‌ی مانند هورمون‌ها، فاکتورهای رشد و سلول‌های داربستی نیز بکار رفته است ولی فر...
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ژورنال
عنوان ژورنال: European Respiratory Review
سال: 2005
ISSN: 0905-9180,1600-0617
DOI: 10.1183/09059180.05.00009703